The Nigerian Tax System has undergone significant changes in recent times. The Tax Laws are being reviewed with the aim of repelling obsolete provisions and simplifying the main ones. In evaluating the tax regulation in Nigeria, we must address the plight of SMEs. How has tax regulation affected the SMEs operation in Nigeria? How can they get the required professional help from the concerned practitioners so that they don’t get slammed by the sledge hammer of the 3 tiers of Government?